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Competition and intrinsic displacement effects in overloaded weak affinity chromatography


Reference:

Hubble, J., 2001. Competition and intrinsic displacement effects in overloaded weak affinity chromatography. Separation Science and Technology, 36 (4), pp. 541-554.

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Abstract

A simple model is presented that describes the competitive adsorption of two components in a weak affinity adsorption system. Unlike previous models, the approach used here allows description of nonlinear isotherms operated under overloaded conditions. The results obtained suggest that, unlike std. elution protocols, significant concn. effects can be achieved in zonal operation as a result of intrinsic displacement effects, where a more strongly bound contaminant displaces a weakly bound product. [on SciFinder (R)]

Details

Item Type Articles
CreatorsHubble, J.
Uncontrolled Keywordscompetition and intrinsic displacement effects in overloaded weak affinity chromatog.), adsorption (competitive, affinity chromatography (weak, preparative chromatography, adsorption isotherm overloaded weak affinity chromatog, simulation and modeling (competition and intrinsic displacement effects in overloaded weak affinity chromatog.)
DepartmentsFaculty of Engineering & Design > Chemical Engineering
RefereedYes
StatusPublished
ID Code1044

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