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Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography


Reference:

Steele, D. F., Moreton, R. C., Staniforth, J. N., Young, P. M., Tobyn, M. J. and Edge, S., 2008. Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography. AAPS Journal, 10 (3), pp. 494-503.

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Official URL:

http://dx.doi.org/10.1208/s12248-008-9057-0

Abstract

Surface energy data for samples of microcrystalline cellulose have been obtained using two techniques: capillary intrusion and inverse gas chromatography. Ten microcrystalline cellulose materials, studied using capillary intrusion, showed significant differences in the measured surface energetics (in terms of total surface energy and the acid-base characteristics of the cellulose surface), with variations noted between the seven different manufacturers who produced the microcrystalline cellulose samples. The surface energy data from capillary intrusion was similar to data obtained using inverse gas chromatography with the column maintained at 44% relative humidity for the three samples of microcrystalline cellulose studied. This suggests that capillary intrusion may be a suitable method to study the surface energy of pharmaceutical samples.

Details

Item Type Articles
CreatorsSteele, D. F., Moreton, R. C., Staniforth, J. N., Young, P. M., Tobyn, M. J. and Edge, S.
DOI10.1208/s12248-008-9057-0
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code12341

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