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Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery Strategies


Reference:

Blagbrough, I. S. and Zara, C., 2009. Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery Strategies. Pharmaceutical Research, 26 (1), pp. 1-18.

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    Official URL:

    http://dx.doi.org/10.1007/s11095-008-9646-8

    Abstract

    Nanoparticles, including lipopolyamines leading to lipoplexes, liposomes, and polyplexes are targeted drug carrier systems in the current search for a successful delivery system for polynucleic acids. This review is focused on the impact of gene and siRNA delivery for studies of efficacy, pharmacodynamics, and pharmacokinetics within the setting of the wide variety of in vivo animal models now used. This critical appraisal of the recent literature sets out the different models that are currently being investigated to bridge from studies in cell lines through towards clinical reality. Whilst many scientists will be familiar with rodent (murine, fecine, cricetine, and musteline) models, few probably think of fish as a clinically relevant animal model, but zebrafish, madake, and rainbow trout are all being used. Larger animal models include rabbit, cat, dog, and cow. Pig is used both for the prevention of foot-and-mouth disease and human diseases, sheep is a model for corneal transplantation, and the horse naturally develops arthritis. Non-human primate models (macaque, common marmoset, owl monkey) are used for preclinical gene vector safety and efficacy trials to bridge the gap prior to clinical studies. We aim for the safe development of clinically effective delivery systems for DNA and RNAi technologies.

    Details

    Item Type Articles
    CreatorsBlagbrough, I. S.and Zara, C.
    DOI10.1007/s11095-008-9646-8
    Uncontrolled Keywordsgene delivery, pharmacodynamics, efficacy, rnai, pharmacokinetics
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Publisher StatementBlagbo.pdf: This is a SpringerOpen article, published under a Creative Commons Attribution Licence. Blagbrough, I. and C. Zara (2009). "Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA Delivery Strategies." Pharmaceutical Research 26(1): 1-18. DOI: http://dx.doi.org/10.1007/s11095-008-9646-8
    RefereedYes
    StatusPublished
    ID Code12395

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