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Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture


Reference:

Chaudhuri, J. B., Davidson, M. G., Ellis, M. J., Jones, M. D. and Wu, X. J., 2008. Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture. Macromolecular Symposia, 272 (1), pp. 52-57.

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Official URL:

http://dx.doi.org/10.1002/masy.200851206

Abstract

Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.

Details

Item Type Articles
CreatorsChaudhuri, J. B., Davidson, M. G., Ellis, M. J., Jones, M. D. and Wu, X. J.
DOI10.1002/masy.200851206
Uncontrolled Keywordstissue engineering, thin film, biodegradable, scaffold, honeycomb
DepartmentsFaculty of Engineering & Design > Chemical Engineering
Faculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code12444
Additional InformationInternational Conference on (Bio)degradable Polymers from Renewable Resources Vienna, AUSTRIA, NOV 18-21, 2007

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