Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture
Chaudhuri, J. B., Davidson, M. G., Ellis, M. J., Jones, M. D. and Wu, X. J., 2008. Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture. Macromolecular Symposia, 272 (1), pp. 52-57.
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Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.
|Creators||Chaudhuri, J. B., Davidson, M. G., Ellis, M. J., Jones, M. D. and Wu, X. J.|
|Uncontrolled Keywords||tissue engineering, thin film, biodegradable, scaffold, honeycomb|
|Departments||Faculty of Engineering & Design > Chemical Engineering|
Faculty of Science > Chemistry
|Additional Information||International Conference on (Bio)degradable Polymers from Renewable Resources Vienna, AUSTRIA, NOV 18-21, 2007|
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