A simple chiral derivatisation protocol for H-1 NMR spectroscopic analysis of the enantiopurity of O-silyl-1,2-amino alcohols
Powell, M. E., Kelly, A. M., Bull, S. D. and James, T. D., 2009. A simple chiral derivatisation protocol for H-1 NMR spectroscopic analysis of the enantiopurity of O-silyl-1,2-amino alcohols. Tetrahedron Letters, 50 (8), pp. 876-879.
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A simple chiral derivatisation protocol for determining the enantiopurity of O-silyl-protected-1,2-amino alcohols by H-1 NMR spectroscopic analysis is described, which involves their treatment with 2-formylphenylboronic acid and enantiopure (syn)-methyl-2,3-dihydroxy-3-phenylpropionate to afford mixtures of imino-boronate esters whose diastereoisomeric ratio is an accurate reflection of the enantiopurity of the parent amino alcohol.
|Creators||Powell, M. E., Kelly, A. M., Bull, S. D. and James, T. D.|
|Uncontrolled Keywords||2-amino alcohol,1,chiral derivatisation agent,h-1 nmr spectroscopy,enantiomeric excess,boronate esters|
|Departments||Faculty of Science > Chemistry|
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