A Practical Synthesis of α-Substituted tert-Butyl Acrylates from Meldrum's Acid and Aldehydes
Frost, C. G., Penrose, S. D. and Gleave, R., 2009. A Practical Synthesis of α-Substituted tert-Butyl Acrylates from Meldrum's Acid and Aldehydes. Synthesis, 4, pp. 627-635.
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An expeditious synthesis of α-substituted tert-butyl acrylates from commercially available aldehydes and Meldrum's acid has been established. The method benefits from a telescoped condensation-reduction sequence to afford 5-monosubstituted Meldrum's acid derivatives followed by a Mannich-type reaction triggered by a rapid cycloreversion of the dioxinone ring on heating with tert-butyl alcohol.
|Creators||Frost, C. G., Penrose, S. D. and Gleave, R.|
|Uncontrolled Keywords||tandem reactions, mannich bases, alkenes, acrylate derivatives|
|Departments||Faculty of Science > Chemistry|
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