Dye diffusion from microcapsules with different shell thickness into mammalian skin

Reference:

Yow, H. N., Wu, X., Routh, A. F. and Guy, R. H., 2009. Dye diffusion from microcapsules with different shell thickness into mammalian skin. European Journal of Pharmaceutics and Biopharmaceutics, 72 (1), pp. 62-68.

Related documents:

Official URL:

http://dx.doi.org/10.1016/j.ejpb.2008.11.004

Abstract

Oil-in-water microcapsules with varying shell thicknesses were fabricated via a coacervation technique, whereby evaporation of volatile solvents induced the shell-forming polymer to precipitate, phase separate and migrate to the oil/water interface to form microcapsules. These microcapsules encapsulated a lipophilic dye within their cores and were applied topically onto porcine skin for 6 h. Results indicated that the dye preferentially accumulated within the skin furrows and hair follicles, though the dye did not penetrate beyond the stratum corneum. A model estimates the diffusion coefficients of dye through the microcapsule shell and within the skin to be approximately 10(-18) and 10(-16) m(2) s(-1), respectively.

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