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Rhodium-catalyzed 1,4-additions to enantiopure acceptors: asymmetric synthesis of functionalized pyrrolizidinones


Reference:

Zoute, L., Kociok-Kohn, G. and Frost, C. G., 2009. Rhodium-catalyzed 1,4-additions to enantiopure acceptors: asymmetric synthesis of functionalized pyrrolizidinones. Organic Letters, 11 (12), pp. 2491-2494.

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Official URL:

http://dx.doi.org/10.1021/ol900843a

Abstract

The rhodium-catalyzed 1,4-addition of arylboronic acids to an enantiopure heterocyclic acceptor proceeds under ligand control to effect an asymmetric synthesis of functionalized pyrrolizidinones. The protocol allows convenient access to all four stereoisomers of pyrrolizidinone 3a (Ar = Ph) by appropriate selection of substrate and catalyst.

Details

Item Type Articles
CreatorsZoute, L., Kociok-Kohn, G. and Frost, C. G.
DOI10.1021/ol900843a
DepartmentsFaculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code14732

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