Structures of native human thymidine phosphorylase and in complex with 5-iodouracil
Mitsiki, E., Papageorgiou, A. C., Iyer, S., Thiyagarajan, N., Prior, S. H., Sleep, D., Finnis, C. and Acharya, K. R., 2009. Structures of native human thymidine phosphorylase and in complex with 5-iodouracil. Biochemical and Biophysical Research Communications, 386 (4), pp. 666-670.
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Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP and its complex with a substrate 5-iodouracil (5IUR) at 3.0 and 2.5 angstrom, respectively. in addition, we provide information on the role of specific residues in the enzymatic activity of hTP through mutagenesis and kinetic Studies.
|Creators||Mitsiki, E., Papageorgiou, A. C., Iyer, S., Thiyagarajan, N., Prior, S. H., Sleep, D., Finnis, C. and Acharya, K. R.|
|Departments||Faculty of Science > Biology & Biochemistry|
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