Label-free detection of DNA hybridization with Au/SiO2/Si diodes and poly-Si TFTs

Reference:

Estrela, P., Stewart, A. G., Migliorato, P. and Maeda, H., 2004. Label-free detection of DNA hybridization with Au/SiO2/Si diodes and poly-Si TFTs. In: Techical Digest of IEEE International Electron Devices Meeting. IEEE, pp. 1009-1012.

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Official URL:

http://dx.doi.org/10.1109/IEDM.2004.1419359

Abstract

Label-free electrical detection of DNA hybridization has been achieved by employing Au/SiO2/Si MOS diodes and Poly-Si TFTs. The detection is based on the modulation of the gate voltage associated with the increased negative charge on the gate upon hybridization. The method can be applied to other bio-reactions that result in a modification of surface dipoles.

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