The CCN family of proteins: structure-function relationships


Holbourn, K. P., Acharya, K. R. and Perbal, B., 2008. The CCN family of proteins: structure-function relationships. Trends in Biochemical Sciences, 33 (10), pp. 461-473.

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The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.


Item Type Articles
CreatorsHolbourn, K. P., Acharya, K. R. and Perbal, B.
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Uncontrolled Keywordsextracellular-matrix,crystal-structure,tissue growth-factor,factor-binding-proteins,vascular endothelial-cells,fibroblasts,vonwillebrand-factor,heparin-binding,igfbp superfamily,mouse embryonic,bone morphogenetic proteins
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code15558


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