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Conversion of Alcohols into Amines by Borrowing Hydrogen


Reference:

Hamid, M. H. S. A., 2008. Conversion of Alcohols into Amines by Borrowing Hydrogen. Thesis (Doctor of Philosophy (PhD)). University of Bath.

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    Abstract

    This thesis describes the development of a more economical catalytic system for the N-alkylation of amines by “borrowing hydrogen” and its application in the synthesis of a variety of amines including the dopamine agonist Piribedil and the antihistamine agents Antergan and Tripelennamine. Chapter 2 describes the development of the ruthenium-catalysed N-alkylation of primary amines with primary alcohols by “borrowing hydrogen”. Chapter 3 describes the application of the ruthenium-catalysed N-alkylation of secondary amines with primary alcohols by “borrowing hydrogen”. The ruthenium-catalysed synthesis of dimethylamines by “borrowing hydrogen” is also described and a mechanistic proposal for the N-alkylation of alcohols with amines has been proposed. Chapter 4 describes the role of amines in pharmaceuticals and the ruthenium-catalysed synthesis of Piribedil, Antergan and Tripelennamine by “borrowing hydrogen”.

    Details

    Item Type Thesis (Doctor of Philosophy (PhD))
    CreatorsHamid, M. H. S. A.
    Uncontrolled Keywordscatalysis, amination, n-alkylation, amines, ruthenium
    DepartmentsFaculty of Science > Chemistry
    Faculty of Humanities & Social Sciences > Education
    Publisher StatementUnivBath_PhD_2008_MHSA_Hamid.pdf: ©The Author
    StatusUnpublished
    ID Code15587

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