Research

The initial release of cisplatin from poly(lactide-co-glycolide) microspheres


Reference:

Lee, Y. S., Lowe, J. P., Gilby, E., Perera, S. P. and Rigby, S. P., 2010. The initial release of cisplatin from poly(lactide-co-glycolide) microspheres. International Journal of Pharmaceutics, 383 (1-2), pp. 244-254.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1016/j.ijpharm.2009.09.021

Abstract

PLGA microspheres loaded with cisplatin were produced using a single emulsion method. A semi-empirical model, with bi-exponential terms, was found to give a better fit to the drug release profiles compared to a mono-exponential model. This model suggests that there are two separate fractions of drug present in the depot. A fraction of the drug is located near/at the surface of the depot, and is readily released during immersion in buffer. A second fraction of drug is entrapped deeper within the depot and is subsequently released. It was also found that the initial release of cisplatin from PLGA microsphere is highly diffusion-controlled and the classical Higuchi model provides a good fit. From studies of water diffusion using PFG-NMR, results suggested that 50:50 PLGA microsphere was most susceptible to swelling and this might have promoted the faster initial drug release. Results from NMR cryoporometry also indicated that the developed PLGA microspheres could have "ink-bottle" pores. (C) 2009 Elsevier B.V. All rights reserved.

Details

Item Type Articles
CreatorsLee, Y. S., Lowe, J. P., Gilby, E., Perera, S. P. and Rigby, S. P.
DOI10.1016/j.ijpharm.2009.09.021
DepartmentsFaculty of Engineering & Design > Chemical Engineering
Faculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code17473

Export

Actions (login required)

View Item