Research

Evolution of MRSA during hospital transmission and intercontinental spread


Reference:

Harris, S. R., Feil, E. J., Holden, M. T. G., Quail, M. A., Nickerson, E. K., Chantratita, N., Gardete, S., Tavares, A., Day, N., Lindsay, J. A., Edgeworth, J. D., de Lencastre, H., Parkhill, J., Peacock, S. J. and Bentley, S. D., 2010. Evolution of MRSA during hospital transmission and intercontinental spread. Science, 327 (5964), pp. 469-474.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1126/science.1182395

Abstract

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

Details

Item Type Articles
CreatorsHarris, S. R., Feil, E. J., Holden, M. T. G., Quail, M. A., Nickerson, E. K., Chantratita, N., Gardete, S., Tavares, A., Day, N., Lindsay, J. A., Edgeworth, J. D., de Lencastre, H., Parkhill, J., Peacock, S. J. and Bentley, S. D.
DOI10.1126/science.1182395
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code17799

Export

Actions (login required)

View Item