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Fabrication of BioFET Linear Array for Detection of Protein Interactions


Reference:

Wang, L., Estrela, P., Huq, E., Li, P., Thomas, S., Ko Ferrigno, P., Paul, D., Adkin, P. and Migliorato, P., 2010. Fabrication of BioFET Linear Array for Detection of Protein Interactions. Microelectronic Engineering, 87 (5-8), pp. 753-755.

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Official URL:

http://dx.doi.org/10.1016/j.mee.2009.11.148

Abstract

An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.

Details

Item Type Articles
CreatorsWang, L., Estrela, P., Huq, E., Li, P., Thomas, S., Ko Ferrigno, P., Paul, D., Adkin, P. and Migliorato, P.
DOI10.1016/j.mee.2009.11.148
DepartmentsFaculty of Engineering & Design > Electronic & Electrical Engineering
Research CentresCentre for Advanced Sensor Technologies (CAST)
RefereedYes
StatusPublished
ID Code18027
Additional InformationThe 35th International Conference on Micro- and Nano-Engineering (MNE), The 35th International Conference on Micro- and Nano-Engineering (MNE)

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