Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes

Reference:

Holdroyd, R. S., Page, M. J., Warren, M. R. and Whittlesey, M. K., 2010. Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes. Tetrahedron Letters, 51 (3), pp. 557-559.

Related documents:

Official URL:

http://dx.doi.org/10.1016/j.tetlet.2009.11.090

Abstract

Mild heating of the ring-expanded N-heterocyclic Carbenes 7-Mes and 6-Mes results in intramolecular insertion of the carbene into an ortho-methyl C-H bond. In the presence of traces of acid, the resulting products ring-open to afford N-alkyl indoles. (C) 2009 Elsevier Ltd. All rights reserved.

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