Research

Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus


Reference:

Massey, R. C., Buckling, A. and Peacock, S. J., 2001. Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus. Current Biology, 11 (22), pp. 1810-1814.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below.

Official URL:

http://dx.doi.org/10.1016/S0960-9822(01)00507-3

Abstract

Bacterial antibiotic resistance is often associated with a fitness cost in the absence of the antibiotic [1] and [2]. We have examined a resistance mechanism in Staphylococcus aureus that negates these costs. Exposure to gentamicin both in vitro and in vivo has been reported to result in the emergence of a gentamicin-resistant small colony variant (SCV) [3], [4], [5], [6], [7] and [8]. We show that the emergence of SCVs following exposure to gentamicin results from a rapid switch and that bacteria exposed to cycles of gentamicin followed by antibiotic-free medium repeatedly switched between a resistant SCV and a sensitive parental phenotype (revertants). The fitness of revertants relative to S. aureus with stable gentamicin resistance was greater in drug-free media, which suggests that S. aureus has evolved an inducible and reversible resistance mechanism that circumvents a permanent cost to fitness.

Details

Item Type Articles
CreatorsMassey, R. C., Buckling, A. and Peacock, S. J.
DOI10.1016/S0960-9822(01)00507-3
DepartmentsFaculty of Science > Biology & Biochemistry
RefereedYes
StatusPublished
ID Code18182

Export

Actions (login required)

View Item