Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus
Massey, R. C., Buckling, A. and Peacock, S. J., 2001. Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus. Current Biology, 11 (22), pp. 1810-1814.
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Bacterial antibiotic resistance is often associated with a fitness cost in the absence of the antibiotic  and . We have examined a resistance mechanism in Staphylococcus aureus that negates these costs. Exposure to gentamicin both in vitro and in vivo has been reported to result in the emergence of a gentamicin-resistant small colony variant (SCV) , , , ,  and . We show that the emergence of SCVs following exposure to gentamicin results from a rapid switch and that bacteria exposed to cycles of gentamicin followed by antibiotic-free medium repeatedly switched between a resistant SCV and a sensitive parental phenotype (revertants). The fitness of revertants relative to S. aureus with stable gentamicin resistance was greater in drug-free media, which suggests that S. aureus has evolved an inducible and reversible resistance mechanism that circumvents a permanent cost to fitness.
|Creators||Massey, R. C., Buckling, A. and Peacock, S. J.|
|Departments||Faculty of Science > Biology & Biochemistry|
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