Oligomeric alpha-synuclein and its role in neuronal death

Reference:

Brown, D. R., 2010. Oligomeric alpha-synuclein and its role in neuronal death. IUBMB Life, 62 (5), pp. 334-339.

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Official URL:

http://dx.doi.org/10.1002/iub.316

Abstract

Alpha-synuclein is a natively unfolded protein associated with a number of neurodegenerative disorders that include Parkinson's disease. In the past, research has focused on the fibrillar form of the protein. Current research now indicates that oligomeric alpha-synuclein is the form of the protein most likely to causes neuronal death. Recent research has suggested that a unique oligomer associated with the copper binding capacity of the protein is the neurotoxic form of the protein. This review looks at the evidence for this possibility.

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