Protein arginine methylation: a new handle on T lymphocytes?
Parry, R. V. and Ward, S. G., 2010. Protein arginine methylation: a new handle on T lymphocytes? Trends in Immunology, 31 (4), pp. 164-169.
Related documents:This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)
Protein arginine methylation has emerged as a key regulator of signal transduction with an important role in T lymphocyte activation. The predominant methyl transferase PRMT-1 is highly expressed in T helper cells, and ligation of the T cell antigen and costimulatory receptors, induces arginine methylation on several cytoplasmic proteins. Global inhibition of methyl transferases can result in signaling defects in CD4 T cells and profound immunosuppression. Here we suggest that manipulating protein arginine methylation could be a feasible strategy to modulate T lymphocyte function, presenting a novel approach towards immunotherapy and the treatment of T cell-mediated disorders such as autoimmune disease and transplant rejection.
|Creators||Parry, R. V.and Ward, S. G.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
Actions (login required)