Protein arginine methylation: a new handle on T lymphocytes?

Reference:

Parry, R. V. and Ward, S. G., 2010. Protein arginine methylation: a new handle on T lymphocytes? Trends in Immunology, 31 (4), pp. 164-169.

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Official URL:

http://dx.doi.org/10.1016/j.it.2010.01.006

Abstract

Protein arginine methylation has emerged as a key regulator of signal transduction with an important role in T lymphocyte activation. The predominant methyl transferase PRMT-1 is highly expressed in T helper cells, and ligation of the T cell antigen and costimulatory receptors, induces arginine methylation on several cytoplasmic proteins. Global inhibition of methyl transferases can result in signaling defects in CD4 T cells and profound immunosuppression. Here we suggest that manipulating protein arginine methylation could be a feasible strategy to modulate T lymphocyte function, presenting a novel approach towards immunotherapy and the treatment of T cell-mediated disorders such as autoimmune disease and transplant rejection.

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