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Characterisation and functionality of inhalation anhydrous lactose


Reference:

Pitchayajittipong, C., Price, R., Shur, J., Kaerger, J. S. and Edge, S., 2010. Characterisation and functionality of inhalation anhydrous lactose. International Journal of Pharmaceutics, 390 (2), pp. 134-141.

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Official URL:

http://dx.doi.org/10.1016/j.ijpharm.2010.01.028

Abstract

The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200 mu g) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49 mu g. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.

Details

Item Type Articles
CreatorsPitchayajittipong, C., Price, R., Shur, J., Kaerger, J. S. and Edge, S.
DOI10.1016/j.ijpharm.2010.01.028
Uncontrolled Keywordspowder fluidisation, anhydrous lactose, dry powder inhaler
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code19095

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