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Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase


Reference:

Suaifan, G., Goodyer, C. L. M. and Threadgill, M. D., 2010. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase. Molecules, 15 (5), pp. 3121-3134.

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Official URL:

http://dx.doi.org/10.3390/molecules15053121

Abstract

Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).

Details

Item Type Articles
CreatorsSuaifan, G., Goodyer, C. L. M. and Threadgill, M. D.
DOI10.3390/molecules15053121
Uncontrolled Keywordsstimulation, thienylmethylthioureas, inos, nitric oxide synthase
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code19194

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