Cu(II) homogeneous and heterogeneous catalysts for the asymmetric Henry reaction

Reference:

Jones, M., Cooper, C., Mahon, M. F., Raithby, P. R., Apperley, D., Wolowska, J. and Collison, D., 2010. Cu(II) homogeneous and heterogeneous catalysts for the asymmetric Henry reaction. Journal of Molecular Catalysis A: Chemical, 325 (1-2), pp. 8-14.

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Official URL:

http://dx.doi.org/10.1016/j.molcata.2010.03.013

Abstract

New Cu(II) complexes have been prepared and characterised via single crystal X-ray diffraction studies, EPR spectroscopy, elemental analysis and high resolution mass spectrometry. In all cases 1:2 (copper to ligand) stoichiometric complexes were isolated. The homogeneous Cu(II) complexes were tested for the asymmetric Henry reaction. Conversions in excess of 70% were obtained with enantioselectivities in the range 0-78%. Heterogeneous Cu(II) catalysts have been prepared. In these cases high conversions were obtained. However, after prolonged reaction time the main product observed was 1,3-dinitro-2-phenyl propane. The formation of this product can be curtailed by both decreasing the catalyst loading and employing shorter reaction times.

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