Research

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide


Reference:

Blagbrough, I. S., Geall, A. J. and David, S. A., 2000. Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide. Bioorganic & Medicinal Chemistry Letters, 10 (17), pp. 1959-1962.

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Abstract

Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

Details

Item Type Articles
CreatorsBlagbrough, I. S., Geall, A. J. and David, S. A.
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code19789

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