Research

Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes


Reference:

Anderson, N. J., Robinson, E. S. J., Husbands, S. M., Delagrange, P., Nutt, D. J. and Hudson, A. L., 2003. Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes. Annals of the New York Academy of Sciences, 1009 (1), pp. 175-179.

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Official URL:

http://dx.doi.org/10.1196/annals.1304.020

Abstract

This study investigates the binding of [3H]harmane to rat whole brain homogenates. Saturation studies revealed [3H]harmane labels a single, saturable, high-capacity population with high affinity. All the test compounds displaced [3H]harmane completely and in an apparently monophasic manner. The displacement profile of the test ligands indicated labeling of MAO-A. Given the high level of MAO-A binding, it is unlikely that a low-capacity I2 site would be distinguishable from the total [3H]harmane population.

Details

Item Type Articles
CreatorsAnderson, N. J., Robinson, E. S. J., Husbands, S. M., Delagrange, P., Nutt, D. J. and Hudson, A. L.
DOI10.1196/annals.1304.020
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code19816

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