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A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions


Reference:

White, J. R., Price, G. J., Schiffers, S., Raithby, P. R., Plucinski, P. K. and Frost, C. G., 2010. A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions. Tetrahedron Letters, 51 (30), pp. 3913-3917.

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Official URL:

http://dx.doi.org/10.1016/j.tetlet.2010.05.104

Abstract

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

Details

Item Type Articles
CreatorsWhite, J. R., Price, G. J., Schiffers, S., Raithby, P. R., Plucinski, P. K. and Frost, C. G.
DOI10.1016/j.tetlet.2010.05.104
DepartmentsFaculty of Engineering & Design > Chemical Engineering
Faculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code20171

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