A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions
White, J. R., Price, G. J., Schiffers, S., Raithby, P. R., Plucinski, P. K. and Frost, C. G., 2010. A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions. Tetrahedron Letters, 51 (30), pp. 3913-3917.
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The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.
|Creators||White, J. R., Price, G. J., Schiffers, S., Raithby, P. R., Plucinski, P. K. and Frost, C. G.|
|Departments||Faculty of Engineering & Design > Chemical Engineering|
Faculty of Science > Chemistry
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