Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells
Reference:
Dobbin, E., Corrigan, P. M., Walsh, C. P., Welham, M. J., Freeburn, R. W. and Wheadon, H., 2008. Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32 (10), pp. 1554-1564.
Related documents:
This repository does not currently have the full-text of this item.You may be able to access a copy if URLs are provided below. (Contact Author)
Official URL:
http://dx.doi.org/10.1016/j.leukres.2008.02.007
Abstract
The leukemic oncogene Tel/PDGFR beta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFR beta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFR beta-expressing cells. This study indicates Tel/PDGFR beta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.
Details
| Item Type | Articles |
| Creators | Dobbin, E., Corrigan, P. M., Walsh, C. P., Welham, M. J., Freeburn, R. W. and Wheadon, H. |
| DOI | 10.1016/j.leukres.2008.02.007 |
| Departments | Faculty of Science > Pharmacy & Pharmacology |
| Refereed | Yes |
| Status | Published |
| ID Code | 20218 |
Export
Actions (login required)
| View Item |
