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Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells


Reference:

Dobbin, E., Corrigan, P. M., Walsh, C. P., Welham, M. J., Freeburn, R. W. and Wheadon, H., 2008. Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32 (10), pp. 1554-1564.

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Official URL:

http://dx.doi.org/10.1016/j.leukres.2008.02.007

Abstract

The leukemic oncogene Tel/PDGFR beta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFR beta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFR beta-expressing cells. This study indicates Tel/PDGFR beta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.

Details

Item Type Articles
CreatorsDobbin, E., Corrigan, P. M., Walsh, C. P., Welham, M. J., Freeburn, R. W. and Wheadon, H.
DOI10.1016/j.leukres.2008.02.007
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code20218

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