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Sex differences in hypothalamic-pituitary-adrenal axis function in patients with chronic pain syndrome


Reference:

Turner-Cobb, J. M., Osborn, M., da Silva, L., Keogh, E. and Jessop, D. S., 2010. Sex differences in hypothalamic-pituitary-adrenal axis function in patients with chronic pain syndrome. Stress - The International Journal on the Biology of Stress, 13 (4), pp. 293-301.

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    Official URL:

    http://dx.doi.org/10.3109/10253890903524785

    Abstract

    Chronic pain is often equated with chronic stress yet the relationship between chronic pain and hypothalamic-pituitary-adrenal (HPA) axis activity is poorly understood. The objective of this study was to examine diurnal functioning of the HPA axis in patients with clinically defined non-inflammatory chronic pain syndrome (CPS) compared to controls. The sample consisted of 37 adults with CPS and 47 healthy controls. All participants provided saliva samples at awakening, 12: 00, 18: 00 and 21: 00 h on two consecutive days, as well as completing self-report questionnaires relating to anxiety and depression. The CPS group had a significantly lower overall mean diurnal salivary cortisol concentration compared to the control group (p < 0.01) but no significant differences were found between the two groups for repeated cortisol sampling across the day. However, a three-way interaction of time of day by patient status by sex was found (p < 0.032), with lower cortisol concentration in male patients compared to female patients in the afternoon period. No significant group effect was found for the rate of decline in the circadian rise in cortisol concentration. These data demonstrate that CPS is associated with a degree of hypocortisolemia, particularly in male patients. The altered dynamics of cortisol secretion in CPS in relation to the onset and duration of pain in patients remains to be determined.

    Details

    Item Type Articles
    CreatorsTurner-Cobb, J. M., Osborn, M., da Silva, L., Keogh, E. and Jessop, D. S.
    DOI10.3109/10253890903524785
    Uncontrolled Keywordshypocortisolemia, hpa axis, chronic stress, salivary cortisol, chronic pain syndrome, sex differences
    DepartmentsFaculty of Humanities & Social Sciences > Psychology
    Publisher StatementTurnerCobb_IJBS_2010_13_4_293.pdf: This is an electronic version of an article published in Turner-Cobb, J. M., Osborn, M., da Silva, L., Keogh, E., Jessop, D. S., 2010. Sex differences in hypothalamic-pituitary-adrenal axis function in patients with chronic pain syndrome. Stress - The International Journal on the Biology of Stress, 13 (4), pp. 293-301. Stress - The International Journal of the Biology of Stress is available online at: http://dx.doi.org/10.3109/10253890903524785
    RefereedYes
    StatusPublished
    ID Code20258

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