Research

Reprogramming of liver to pancreas


Reference:

Thowfeequ, S., Li, W.-C., Slack, J. M. and Tosh, D., 2009. Reprogramming of liver to pancreas. In: Audet, J. and Stanford, W. L., eds. Stem Cells in Regenerative Medicine.482 ed. Humana Press, pp. 407-418. (Methods in Molecular Biology)

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Official URL:

http://dx.doi.org/10.1007/978-1-59745-060-7_25

Abstract

Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.

Details

Item Type Book Sections
CreatorsThowfeequ, S., Li, W.-C., Slack, J. M. and Tosh, D.
EditorsAudet, J.and Stanford, W. L.
DOI10.1007/978-1-59745-060-7_25
DepartmentsFaculty of Science > Biology & Biochemistry
StatusPublished
ID Code20347

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