Reprogramming of liver to pancreas


Thowfeequ, S., Li, W.-C., Slack, J. M. and Tosh, D., 2009. Reprogramming of liver to pancreas. In: Audet, J. and Stanford, W. L., eds. Stem Cells in Regenerative Medicine.482 ed. Humana Press, pp. 407-418. (Methods in Molecular Biology)

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Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors.


Item Type Book Sections
CreatorsThowfeequ, S., Li, W.-C., Slack, J. M. and Tosh, D.
EditorsAudet, J.and Stanford, W. L.
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code20347


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