New sources of β-cells for treating diabetes

Reference:

Saha, S., Tosh, D. and Hardikar, A. A., 2009. New sources of β-cells for treating diabetes. Journal of Endocrinology, 202 (1), pp. 13-16.

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Official URL:

http://dx.doi.org/10.1677/JOE-09-0097

Abstract

The treatment of diabetes by islet transplantation is presently hampered by the shortage of organ donors. The generation of insulin-producing cells is therefore a major objective in the long-term goal Of curing diabetes. Alternative Sources of pancreatic beta-cells include existing pancreatic cells, embryonic stern cells, and cells from other tissues such as liver. This commentary considers evidence for two new sources of beta-cells: intrahepatic biliary epithelial cells and gall bladder epithelium. These observations raise the possibility that a patient's,, own cells may be used as a source of insulin-producing cells for cell replacement in diabetes

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