Seven-transmembrane receptor signalling and ERK compartmentalization


Caunt, C. J., Finch, A. R., Sedgley, K. R. and McArdle, C. A., 2006. Seven-transmembrane receptor signalling and ERK compartmentalization. Trends in Endocrinology and Metabolism, 17 (7), pp. 276-283.

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Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.


Item Type Articles
CreatorsCaunt, C. J., Finch, A. R., Sedgley, K. R. and McArdle, C. A.
DepartmentsFaculty of Science > Biology & Biochemistry
ID Code20401


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