Seven-transmembrane receptor signalling and ERK compartmentalization

Reference:

Caunt, C. J., Finch, A. R., Sedgley, K. R. and McArdle, C. A., 2006. Seven-transmembrane receptor signalling and ERK compartmentalization. Trends in Endocrinology and Metabolism, 17 (7), pp. 276-283.

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Official URL:

http://dx.doi.org/10.1016/j.tem.2006.07.008

Abstract

Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.

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