The HPV vaccination strategy: could male vaccination have a significant impact?
Brown, V. and White, K., 2010. The HPV vaccination strategy: could male vaccination have a significant impact? Computational and Mathematical Methods in Medicine, 11 (3), pp. 223-237.
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We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, [image omitted], which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. Results show that waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects [image omitted], as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.
|Creators||Brown, V.and White, K.|
|Uncontrolled Keywords||reproductive value, mathematical modelling, hpv, vaccination|
|Departments||Faculty of Science > Mathematical Sciences|
|Research Centres||Centre for Mathematical Biology|
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