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Self-assembled complex formulations of lipid-aminoglycoside conjugates: nanoparticles for efficient gene and siRNA delivery


Reference:

Ghonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I., 2010. Self-assembled complex formulations of lipid-aminoglycoside conjugates: nanoparticles for efficient gene and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1295-1296.

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Official URL:

http://dx.doi.org/10.1111/j.2042-7158.2010.01178.x

Abstract

We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.

Details

Item Type Articles
CreatorsGhonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I.
DOI10.1111/j.2042-7158.2010.01178.x
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedNo
StatusPublished
ID Code20978
Additional InformationAbstract from the UK PharmSci Conference, 1-3 September 2010.

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