Self-assembled complex formulations of lipid-aminoglycoside conjugates: nanoparticles for efficient gene and siRNA delivery
Ghonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I., 2010. Self-assembled complex formulations of lipid-aminoglycoside conjugates: nanoparticles for efficient gene and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1295-1296.
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We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.
|Creators||Ghonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Additional Information||Abstract from the UK PharmSci Conference, 1-3 September 2010.|
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