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Heterocyclic N-4, N-9-diacyl spermines: nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery


Reference:

Ghonaim, H. M., Soltan, M. K. and Blagbrough, I. S., 2010. Heterocyclic N-4, N-9-diacyl spermines: nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1276-1277.

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Official URL:

http://dx.doi.org/10.1111/j.2042-7158.2010.01178.x

Abstract

We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.

Details

Item Type Articles
CreatorsGhonaim, H. M., Soltan, M. K. and Blagbrough, I. S.
DOI10.1111/j.2042-7158.2010.01178.x
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedNo
StatusPublished
ID Code20979
Additional InformationAbstract from the UK PharmSci Conference, 1-3 September 2010.

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