Heterocyclic N-4, N-9-diacyl spermines:Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery
Ghonaim, H. M., Soltan, M. K. and Blagbrough, I. S., 2010. Heterocyclic N-4, N-9-diacyl spermines:Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1276-1277.
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We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.
|Creators||Ghonaim, H. M., Soltan, M. K. and Blagbrough, I. S.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Additional Information||Abstract from the UK PharmSci Conference, 1-3 September 2010.|
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