Research

Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor


Reference:

Whittaker, R. J., Booth, R., Dyson, R., Bailey, C., Parsons Chini, L., Naire, S., Payvandi, S., Rong, Z., Woollard, H., Cummings, L. J., Waters, S. L., Mawasse, L., Chaudhuri, J. B., Ellis, M. J., Michael, V., Kuiper, N. J. and Cartmell, S., 2009. Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor. Journal of Theoretical Biology, 256 (4), pp. 533-546.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below. (Contact Author)

Official URL:

http://dx.doi.org/10.1016/j.jtbi.2008.10.013

Abstract

We develop a simple mathematical model for forced flow of culture medium through a porous scaffold in a tissue-engineering bioreactor. Porous-walled hollow fibres penetrate the scaffold and act as additional sources of culture medium. The model, based on Darcy's law, is used to examine the nutrient and shear-stress distributions throughout the scaffold. We consider several configurations of fibres and inlet and outlet pipes. Compared with a numerical solution of the full Navier–Stokes equations within the complex scaffold geometry, the modelling approach is cheap, and does not require knowledge of the detailed microstructure of the particular scaffold being used. The potential of this approach is demonstrated through quantification of the effect the additional flow from the fibres has on the nutrient and shear-stress distribution.

Details

Item Type Articles
CreatorsWhittaker, R. J., Booth, R., Dyson, R., Bailey, C., Parsons Chini, L., Naire, S., Payvandi, S., Rong, Z., Woollard, H., Cummings, L. J., Waters, S. L., Mawasse, L., Chaudhuri, J. B., Ellis, M. J., Michael, V., Kuiper, N. J. and Cartmell, S.
DOI10.1016/j.jtbi.2008.10.013
DepartmentsFaculty of Engineering & Design > Chemical Engineering
Research CentresCentre for Regenerative Medicine
RefereedYes
StatusPublished
ID Code21285

Export

Actions (login required)

View Item