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Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure


Reference:

Wu, X., Jones, M. D., Davidson, M. G., Chaudhuri, J. B. and Ellis, M. J., 2011. Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure. Biotechnology Letters, 33 (2), pp. 423-430.

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    Official URL:

    http://dx.doi.org/10.1007/s10529-010-0438-y

    Abstract

    One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

    Details

    Item Type Articles
    CreatorsWu, X., Jones, M. D., Davidson, M. G., Chaudhuri, J. B. and Ellis, M. J.
    DOI10.1007/s10529-010-0438-y
    DepartmentsFaculty of Engineering & Design > Chemical Engineering
    Faculty of Science > Chemistry
    Research CentresCentre for Regenerative Medicine
    Publisher StatementWu_BILE_Honeycomb_2010_REVISED_2.pdf: The original publication is available at www.springerlink.com
    RefereedYes
    StatusPublished
    ID Code21397

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