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A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms


Reference:

McGrath, E. J., Lovell, C. R., Gillison, F., Darvay, A., Hickey, J. R. and Skevington, S. M., 2010. A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms. British Journal of Dermatology, 163 (6), pp. 1323-1329.

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    Official URL:

    http://dx.doi.org/10.1111/j.1365-2133.2010.10060.x

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    Abstract

    Background Isotretinoin is an efficacious treatment for acne, but has been controversially linked with depression. Objectives This study aimed to examine the effects of isotretinoin on quality of life (QoL) and depression using a prospective design. Methods The WHOQOL-BREF QoL measure and Centre for Epidemiological Studies Depression Scale were administered to consecutive outpatients with acne who were prescribed either isotretinoin (n = 65) or antibiotic treatment (n = 31). Patients and physicians rated acne severity independently. Groups were compared at baseline with a matched community sample (n = 94) and measurements repeated at 3 months for treatment groups. Results There were no differences between the three groups at baseline in terms of age, gender, depression or overall QoL. Acne was more severe in the treatment groups (P < 0 001). Depression was negatively correlated with QoL (P < 0 001) and hence was included as a covariate in repeated-measures analyses of QoL. Acne improved over time in both treatment groups (F = 48 2, P < 0 001). There was no detectable deterioration in depression score in either group (F = 1.1, not significant). QoL in the physical and social domains improved (P < 0.001) while psychological and environmental QoL was unchanged over time. The improvement in social QoL was greater in the isotretinoin group (P < 0.05). Those patients with higher baseline depression scores showed greater improvements in physical, psychological and social QoL (P < 0.001). Conclusions Treatment of acne improves QoL, particularly in those with more depressive symptoms at the outset. Mood deterioration was not detected, but the possibility of subtle or rare mood effects of isotretinoin cannot be ruled out.

    Details

    Item Type Articles
    CreatorsMcGrath, E. J., Lovell, C. R., Gillison, F., Darvay, A., Hickey, J. R. and Skevington, S. M.
    DOI10.1111/j.1365-2133.2010.10060.x
    Related URLs
    URLURL Type
    http://www.scopus.com/inward/record.url?scp=78649664248&partnerID=8YFLogxKUNSPECIFIED
    Uncontrolled Keywordswhoqol-bref,quality of life,isotretinoin,depression,acne
    DepartmentsFaculty of Humanities & Social Sciences > Psychology
    Faculty of Humanities & Social Sciences > Health
    Publisher Statementacne_qol_14_Sept_09.pdf: This is the peer reviewed version of the following article: E. J. McGrath, C. R. Lovell, F. Gillison, A. Darvay, J. R Hickey, and S. M. Skevington, 'A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms' in British Journal of Dermatology, Vol. 163, Issue 6, pp. 1323 - 1329, December 2010, which has been published in final form at: DOI: 10.1111/j.1365-2133.2010.10060.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.;Acne_QoL.pdf: This is the peer reviewed version of the following article: E. J. McGrath, C. R. Lovell, F. Gillison, A. Darvay, J. R. Hickey and S. M. Skevington (2010) A Prospective Trial of the Effects of Isotretinoin on Quality of Life and Depressive Symptoms. British Journal of Dermatology, volume 163, Issue 6, pp. 1323 - 1329, December 2010, which has been published in final form at: DOI. 10.1111/j.1365-2133.2010.10060.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    RefereedYes
    StatusPublished
    ID Code22171

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