Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues:a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor
Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. and Potter, B. V. L., 2011. Synthesis of cyclic adenosine 5 '-diphosphate ribose analogues:a C2 ' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Organic and Biomolecular Chemistry, 9 (1), pp. 278-290.
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Novel 8-substituted base and sugar-modified analogues of the Ca2+ mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by H-1 NMR spectroscopy revealed that a C2' endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.
|Creators||Moreau, C., Ashamu, G. A., Bailey, V. C., Galione, A., Guse, A. H. and Potter, B. V. L.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
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