Dissecting the immune response to the entomopathogen Photorhabdus

Reference:

Eleftherianos, I., Ffrench-Constant, R. H., Clarke, D. J., Dowling, A. J. and Reynolds, S. E., 2010. Dissecting the immune response to the entomopathogen Photorhabdus. Trends in Microbiology, 18 (12), pp. 552-560.

Related documents:

Preview

PDF (Reynolds_TiM_2010_18_12_552.pdf) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (380kB) | Preview

Official URL:

http://dx.doi.org/10.1016/j.tim.2010.09.006

Abstract

Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens

Export

Actions (login required)