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Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us?


Reference:

Holbourn, K. P., Perbal, B. and Acharya, K. R., 2010. Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us? In: CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Berlin: Springer, pp. 15-40.

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Official URL:

http://dx.doi.org/10.1007/978-90-481-3779-4_3

Abstract

CCN proteins are modular multifunctional proteins comprised of four discrete domains: (1) an IGFBP domain, (2) a VWC domain, (3) a TSP domain, and (4) a CT domain. These domains give a broad repertoire of functions to the CCN family including angiogenesis, skeletal development tumourigenesis, wound healing, cell proliferation, adhesion and survival. These wide variety of biological functions are enabled due to the multi-domain nature of the protein allowing interactions with an extensive range of ligands and effectors and the possibility of multiple domains acting in concert. A closer look at each domain from a biological and structural perspective could give insights into their function.

Details

Item Type Book Sections
CreatorsHolbourn, K. P., Perbal, B. and Acharya, K. R.
DOI10.1007/978-90-481-3779-4_3
DepartmentsFaculty of Science > Biology & Biochemistry
StatusPublished
ID Code22880
Additional Information5th International Workshop on the CCN Family of Genes. 18-22 October 2008. Toronto, Canada.

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