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Production of pharmaceuticals: amines from alcohols in a continuous flow fixed bed catalytic reactor


Reference:

Lamb, G. W., Al Badran, F. A., Williams, J. M. J. and Kolaczkowski, S. T., 2010. Production of pharmaceuticals: amines from alcohols in a continuous flow fixed bed catalytic reactor. Chemical Engineering Research & Design, 88 (12), pp. 1533-1540.

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Official URL:

http://dx.doi.org/10.1016/j.cherd.2010.04.005

Abstract

This paper reports the use of an immobilised ruthenium complex in a continuous flow process for the N-alkylation of morpholine with benzyl alcohol. The ruthenium-based catalyst was supported on a phosphine bound polymer. Screening experiments were first performed in a batch reactor, with a 16 vol% mixture of morpholine and benzyl alcohol (stoichiometric molar ratio of 1:1) in toluene as the solvent. Operating at 110 degrees C for 24 h, it was shown that high conversions (>99%) into the desired tertiary amine could be achieved. This reaction was then shown to be viable in a continuous flow reactor, where the catalytic polymer beads were retained in the bed. Operating at 150 degrees C and using p-xylene as a solvent, the conversion into the desired tertiary amine was shown to be as high as 98%. This approach is clearly very promising, as it provides a greener and more atom efficient route for the production of secondary and tertiary amines in the pharmaceutical industry.

Details

Item Type Articles
CreatorsLamb, G. W., Al Badran, F. A., Williams, J. M. J. and Kolaczkowski, S. T.
DOI10.1016/j.cherd.2010.04.005
Uncontrolled Keywordscontinuous pharmaceutical processing, production of amines, morpholine, n-alkylation of amines using alcohols, borrowing hydrogen
DepartmentsFaculty of Engineering & Design > Chemical Engineering
Faculty of Science > Chemistry
RefereedYes
StatusPublished
ID Code22882

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