Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines

Reference:

Elmasry, M. S., Blagbrough, I. S., Rowan, M. G., Saleh, H. M., Kheir, A. A. and Rogers, P. J., 2011. Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines. Journal of Pharmaceutical and Biomedical Analysis, 54 (4), pp. 646-652.

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Official URL:

http://dx.doi.org/10.1016/j.jpba.2010.10.002

Abstract

An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C-12 column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.

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