Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.
Massey, P. V., Warburton, E. C., Wynick, D., Brown, M. W. and Bashir, Z. I., 2003. Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. Neuropharmacology, 44 (1), pp. 40-48.
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It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
|Creators||Massey, P. V., Warburton, E. C., Wynick, D., Brown, M. W. and Bashir, Z. I.|
|Departments||Faculty of Science > Pharmacy & Pharmacology|
|Additional Information||ID number: PMID: 12559120|
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