Research

Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.


Reference:

Massey, P. V., Warburton, E. C., Wynick, D., Brown, M. W. and Bashir, Z. I., 2003. Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. Neuropharmacology, 44 (1), pp. 40-48.

Related documents:

This repository does not currently have the full-text of this item.
You may be able to access a copy if URLs are provided below.

Official URL:

http://dx.doi.org/10.1016/S0028-3908(02)00297-6

Abstract

It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.

Details

Item Type Articles
CreatorsMassey, P. V., Warburton, E. C., Wynick, D., Brown, M. W. and Bashir, Z. I.
DOI10.1016/S0028-3908(02)00297-6
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code23418
Additional InformationID number: PMID: 12559120

Export

Actions (login required)

View Item