Research

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression


Reference:

Massey, P. V., Johnson, B. E., Moult, P. R., Auberson, Y. P., Brown, M. W., Molnar, E., Collingridge, G. L. and Bashir, Z. I., 2004. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. Journal of Neuroscience, 24 (36), pp. 7821-7828.

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    Official URL:

    http://dx.doi.org/10.1523/JNEUROSCI.1697-04.2004

    Abstract

    It is widely believed that long-term depression (LTD) and its counterpart, long-term potentiation (LTP), involve mechanisms that are crucial for learning and memory. However, LTD is difficult to induce in adult cortex for reasons that are not known. Here we show that LTD can be readily induced in adult cortex by the activation of NMDA receptors (NMDARs), after inhibition of glutamate uptake. Interestingly there is no need to activate synaptic NMDARs to induce this LTD, suggesting that LTD is triggered primarily by extrasynaptic NMDA receptors. We also find that de novo LTD requires the activation of NR2B-containing NMDAR, whereas LTP requires activation of NR2A-containing NMDARs. Surprisingly another form of LTD, depotentiation, requires activation of NR2A-containing NMDARs. Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex.

    Details

    Item Type Articles
    CreatorsMassey, P. V., Johnson, B. E., Moult, P. R., Auberson, Y. P., Brown, M. W., Molnar, E., Collingridge, G. L. and Bashir, Z. I.
    DOI10.1523/JNEUROSCI.1697-04.2004
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Publisher StatementMassey_et_al_2004.pdf: ©Society for Neuroscience, The Author
    RefereedYes
    StatusPublished
    ID Code23420

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