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Long-term depression: multiple forms and implications for brain function


Reference:

Massey, P. V. and Bashir, Z. I., 2007. Long-term depression: multiple forms and implications for brain function. Trends in Neurosciences, 30 (4), pp. 176-184.

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Official URL:

http://dx.doi.org/10.1016/j.tins.2007.02.005

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) remain widely accepted vertebrate models for the cellular and molecular mechanisms that underlie synaptic changes during learning and memory. Although LTD is a phenomenon that occurs in many regions of the CNS, it is clear that the mechanisms recruited in its induction and expression can vary, depending on many factors, including brain region and developmental time point. LTD in the hippocampus and cerebellum is probably the best characterized, although there are also other brain areas where mechanisms of LTD are well understood, and where it is thought to have a functional role.

Details

Item Type Articles
CreatorsMassey, P. V.and Bashir, Z. I.
DOI10.1016/j.tins.2007.02.005
DepartmentsFaculty of Science > Pharmacy & Pharmacology
RefereedYes
StatusPublished
ID Code23424

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