Research

Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry


Reference:

Baker, D. R. and Kasprzyk-Hordern, B., 2011. Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry. Journal of Chromatography A, 1218 (12), pp. 1620-1631.

Related documents:

[img]
Preview
PDF (Kasprzyk-Horden_J_Chrom_A_2011_1218_12_1620.pdf) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1811kB) | Preview

    Official URL:

    http://dx.doi.org/10.1016/j.chroma.2011.01.060

    Abstract

    A new-multi residue method was developed for the environmental monitoring of 65 stimulants, opiod and morphine derivatives, benzodiazepines, antidepressants, dissociative anaesthetics, drug precursors, human urine indicators and their metabolites in wastewater and surface water. The proposed analytical methodology offers rapid analysis for a large number of compounds, with low limits of quantification and utilises only one solid-phase extraction-ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry (SPE-LC-MS/MS) method, thus overcoming the drawbacks of previously published procedures. The method employed solid phase extraction with the usage of Oasis MCX sorbent and subsequent ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry. The usage of a 1.7 mu m particle size column (1 mm x 150 mm) resulted in very low flow rates (0.04 mL min(-1)), and as a consequence gave good sensitivity, low mobile phase consumption and short retention times for all compounds (from 2.9 to 23.1 min). High SPE recoveries (>60%) were obtained for the majority of compounds. The mean correlation coefficients of the calibration curves were typically higher than 0.997 and showed good linearity in the range 0-1000 mu g L-1. The method limits of detection ranged from 0.1 ng L-1 for compounds including cocaine, benzoylecgonine, norbenzoylecgonine and 2-oxo-3-hydroxy-LSD to 100 ng L-1 for caffeine. Method quantification limits ranged from 0.5 to 154.2 ng L-1. Intra-and inter-day repeatabilities were on average less than 10%. The method accuracy range was within -33.1 to 30.1%. The new multi-residue method was used to analyse drugs of abuse in wastewater and river water in the UK environment. Of the targeted 65 compounds, 46 analytes were detected at levels above the method quantification limit (MQL) in wastewater treatment plant (WWTP) influent, 43 in WWTP effluent and 36 compounds in river water.

    Details

    Item Type Articles
    CreatorsBaker, D. R.and Kasprzyk-Hordern, B.
    DOI10.1016/j.chroma.2011.01.060
    Uncontrolled Keywordsprecursors, wastewater, sewage, spe, surface water, uplc, ms, multi-residue, environment, illicit drugs, drugs of abuse, crack cocaine, pharmaceuticals
    DepartmentsFaculty of Science > Chemistry
    Publisher StatementKasprzyk-Horden_J_Chrom_A_2011_1218_12_1620.pdf: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Chromatography A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chromatography A, vol 1218, issue 12, 2011, DOI 10.1016/j.chroma.2011.01.060; BKH_J_Chrom_A_2011_1218_12_1620.doc: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Chromatography A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chromatography A, vol 1218, issue 12, 2011, DOI 10.1016/j.chroma.2011.01.060
    RefereedYes
    StatusPublished
    ID Code23477

    Export

    Actions (login required)

    View Item

    Document Downloads

    More statistics for this item...