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Antimicrobial activity of ruthenium-based intercalators


Reference:

Bolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A. and Aldrich-Wright, J., 2011. Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, 42 (4), pp. 313-317.

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    Official URL:

    http://dx.doi.org/10.1016/j.ejps.2010.12.004

    Abstract

    Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.

    Details

    Item Type Articles
    CreatorsBolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A. and Aldrich-Wright, J.
    DOI10.1016/j.ejps.2010.12.004
    Uncontrolled Keywordsmethicillin-resistant staphylococcus aureus, dna intercalator, caenorhabditis elegans, ruthenium complexes, antimicrobial agents
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    RefereedYes
    StatusPublished
    ID Code23480

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