Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds
Reference:
Griffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E., 2011. Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds. Organic and Biomolecular Chemistry, 9 (10), pp. 3920-3928.
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Official URL:
http://dx.doi.org/10.1039/c1ob05131h
Abstract
Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence of the halogen leads to reactivity that is distinct to that observed for the non-halogenated analogue and also serves as a synthetic handle for further functionalisation.
Details
| Item Type | Articles |
| Creators | Griffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E. |
| DOI | 10.1039/c1ob05131h |
| Departments | Faculty of Science > Chemistry |
| Refereed | Yes |
| Status | Published |
| ID Code | 23824 |
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