Griffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E., 2011. Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds. Organic and Biomolecular Chemistry, 9 (10), pp. 3920-3928.
Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence of the halogen leads to reactivity that is distinct to that observed for the non-halogenated analogue and also serves as a synthetic handle for further functionalisation.
|Item Type ||Articles|
|Creators||Griffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E.|
|Departments||Faculty of Science > Chemistry|
Actions (login required)