Research

Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds


Reference:

Griffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E., 2011. Expanding the chiral pool: oxidation of meta-bromobenzoic acid by R. eutrophus B9 allows access to new reaction manifolds. Organic and Biomolecular Chemistry, 9 (10), pp. 3920-3928.

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      Official URL:

      http://dx.doi.org/10.1039/c1ob05131h

      Abstract

      Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence of the halogen leads to reactivity that is distinct to that observed for the non-halogenated analogue and also serves as a synthetic handle for further functionalisation.

      Details

      Item Type Articles
      CreatorsGriffen, J. A., Le Coz, A. M., Kociok-Kohn, G., Ali Khan, M., Stewart, A. J. W. and Lewis, S. E.
      DOI10.1039/c1ob05131h
      DepartmentsFaculty of Science > Chemistry
      RefereedYes
      StatusPublished
      ID Code23824

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