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Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K-and GSK-3-dependent signalling


Reference:

Welham, M. J., Kingham, E., Sanchez Ripoll, Y., Kumpfmueller, B., Storm, M. and Bone, H., 2011. Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K-and GSK-3-dependent signalling. Biochemical Society Transactions, 39 (2), pp. 674-678.

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    Official URL:

    http://dx.doi.org/10.1042/bst0390674

    Abstract

    ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the generation of specific cell types for use in regenerative medicine and drug screening. In order to harness their potential, the molecular mechanisms regulating ESC pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3-kinase) and GSK-3 (glycogen synthase kinase 3)-dependent signalling play in the co-ordination and integration of mouse ESC pluripotency and proliferation and contrast this with our understanding of their functions in human ESCs.

    Details

    Item Type Articles
    CreatorsWelham, M. J., Kingham, E., Sanchez Ripoll, Y., Kumpfmueller, B., Storm, M. and Bone, H.
    DOI10.1042/bst0390674
    DepartmentsFaculty of Science > Pharmacy & Pharmacology
    Research CentresCentre for Regenerative Medicine
    Publisher StatementWelham_BST_2011_39_2_674.pdf: The final version of record is available at http://www.biochemsoctrans.org/bst/
    RefereedYes
    StatusPublished
    ID Code23859
    Additional InformationMeeting on Signalling and Human Disease, 25-26 November 2010, Belfast, Ireland.

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