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The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study


Reference:

Brown, V. L. and White, K. A. J., 2011. The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study. Mathematical Biosciences, 231 (2), pp. 126-134.

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Official URL:

http://dx.doi.org/10.1016/j.mbs.2011.02.009

Abstract

Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.

Details

Item Type Articles
CreatorsBrown, V. L.and White, K. A. J.
DOI10.1016/j.mbs.2011.02.009
Uncontrolled Keywordsmathematical model, public health policy, sexually transmitted infection
DepartmentsFaculty of Science > Mathematical Sciences
Research CentresCentre for Mathematical Biology
RefereedYes
StatusPublished
ID Code24112

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