The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study
Reference:
Brown, V. L. and White, K. A. J., 2011. The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study. Mathematical Biosciences, 231 (2), pp. 126-134.
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Official URL:
http://dx.doi.org/10.1016/j.mbs.2011.02.009
Abstract
Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
Details
| Item Type | Articles |
| Creators | Brown, V. L.and White, K. A. J. |
| DOI | 10.1016/j.mbs.2011.02.009 |
| Uncontrolled Keywords | mathematical model, public health policy, sexually transmitted infection |
| Departments | Faculty of Science > Mathematical Sciences |
| Research Centres | Centre for Mathematical Biology |
| Refereed | Yes |
| Status | Published |
| ID Code | 24112 |
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