Research

Galleria mellonella as an infection model for Campylobacter jejuni virulence


Reference:

Senior, N. J., Bagnall, M. C., Champion, O. L., Reynolds, S. E., La Ragione, R. M., Woodward, M. J., Salguero, F. J. and Titball, R. W., 2011. Galleria mellonella as an infection model for Campylobacter jejuni virulence. Journal of Medical Microbiology, 60 (5), pp. 661-669.

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    Official URL:

    http://dx.doi.org/10.1099/jmm.0.026658-0

    Abstract

    Larvae of Galleria mellonella (Greater Wax Moth) have been shown to be susceptible to Campylobacter jejuni infection and our study characterizes this infection model. Following infection with C. jejuni human isolates, bacteria were visible in the haemocoel and gut of challenged larvae, and there was extensive damage to the gut. Bacteria were found in the extracellular and cell-associated fraction in the haemocoel, and it was shown that C. jejuni can survive in insect cells. Finally, we have used the model to screen a further 67 C. jejuni isolates belonging to different MLST types. Isolates belonging to ST257 were the most virulent in the Galleria model, whereas those belonging to ST21 were the least virulent.

    Details

    Item Type Articles
    CreatorsSenior, N. J., Bagnall, M. C., Champion, O. L., Reynolds, S. E., La Ragione, R. M., Woodward, M. J., Salguero, F. J. and Titball, R. W.
    DOI10.1099/jmm.0.026658-0
    DepartmentsFaculty of Science > Biology & Biochemistry
    Publisher StatementReynolds_JMM_2011_60_5_661.pdf: This is an author manuscript that has been accepted for publication in Journal of Medical Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of Medical Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of ‘Fair Use of Copyrighted Materials’ (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://jmm.sgmjournals.org/ and is freely available without a subscription 12 months after publication.
    RefereedYes
    StatusPublished
    ID Code24131

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